CASE REPORT: DIVERSE IMMUNE RESPONSES IN ADVANCED PANCREATIC DUCTAL ADENOCARCINOMA TREATED WITH IMMUNE CHECKPOINT INHIBITOR-BASED CONVERSION THERAPIES

Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at an advanced stage, presenting limited therapeutic options and a grim prognosis due to its aggressive nature.Despite ongoing exploration of various combination therapies, a standardized treatment approach after the first-line treatment progress remains elusive.This report details the case

There is a heightened sensitivity about the risks posed by the prospect of climate change as deduced from the results of the global-regional climate models.Notwithstanding the moderating, albeit feebly articulated, acknowledgement of variability as being an intrinsic attribute of climate, it is often claimed that intensification of large hydrologic

Engine knock determination has been conducted in various ways for spark timing calibration.In the present study, a knock classification model was developed using a machine learning algorithm.Wavelet packet decomposition (WPD) and ensemble empirical mode decomposition (EEMD) were employed for the characterization of the in-cylinder pressure signals

This paper presents the design and development of a new microinjection system with force sensing for automated multi-cell injection in genome editing of zebrafish using the CRISPR/Cas9 system.In comparison Microphone Accessories with the traditional approach, it achieves a high injection speed and high precision of operation, which leads to consist

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder affecting approximately 1-3% of the population.OCD is probably an etiologically heterogeneous condition.Individuals with OCD Loft Bed frequently have additional psychiatric disorders concomitantly or at some time during their lifetime.Recently, some authors proposed an OCD sub-class